Dedifferentiation-associated inflammatory factors of long-term expanded human hepatocytes exacerbate their elimination by macrophages during liver engraftment.

Chenhua Wang,Ludi Zhang,Zhen Sun,Xiang Yuan,Baihua Wu,Jin Cen,Lei Cui,Kun Zhang,Chun Li,Jingqi Wu,Yajing Shu,Wenbin Sun,Jing Wang,Lijian Hui

Hepatology (Baltimore, Md.)（2022）

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摘要

These results revealed that lc-ProliHH triggers exacerbated macrophage activation by DAIF and provided potential solutions for clinical transplantation of lc-ProliHH.

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关键词

Hepatocyte transplantation,hepatocyte culture,innate immune response,macrophage,organoid

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