A Smartphone Application as an Exploratory Endpoint in a Phase 3 Parkinson's Disease Clinical Trial: A Pilot Study.

Alex Page,Norman Yung,Peggy Auinger,Charles Venuto,Alistair Glidden,Eric Macklin,Larsson Omberg,Michael A Schwarzschild,E Ray Dorsey

Digital biomarkers（2022）

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摘要

Introducing a smartphone application midway into a phase 3 clinical trial was challenging. Measures of bradykinesia and gait speed correlated modestly with traditional outcomes and were consistent with the study's overall findings, which found no benefit of the active drug.

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关键词

Clinical trial,Cognition,Gait,Inosine,Movement,Parkinson disease,Smartphone,Telemedicine

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