Cardamomin protects from diabetes-induced kidney damage through modulating PI3K/AKT and JAK/STAT signaling pathways in rats

•CAD enhanced viability and reduced apoptosis of MGO-treated NRK-52E cells.•CAD modulates MGO-induced AGE formation, inflammatory response and oxidative stress in NRK-52E cells.•CAD regulates MGO-induced EMT of NRK-52E cells.•CAD modulates PI3K/AKT and JAK/STAT3 signaling pathways.•CAD ameliorates diabetes-induced kidney damage via regulating PI3K/AKT and JAK/STAT3 signaling pathways.