Obesity induces resistance to central action of BMP8B through a mechanism involving the BBSome

Eva Rial-Pensado,Oscar Freire-Agulleiro,Marcos Ríos,Deng Fu Guo,Cristina Contreras,Patricia Seoane-Collazo,Sulay Tovar,Rubén Nogueiras,Carlos Diéguez,Kamal Rahmouni,Miguel López

Molecular Metabolism（2022）

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摘要

•Central BMP8B induces BAT activation and browning through hypothalamic AMPK.•Obesity elicits resistance to the central effects of BMP8B on energy balance.•Obesity impairs the effect of BMP8B on AMPK, BMP Type I receptors signaling and BBS1 in the hypothalamus.•Lack of BBS1 function recapitulates the thermogenic-induced resistance to central BMP8B.

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关键词

Obesity,Hypothalamus,AMPK,BAT,BMP8B,BBS1

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