Sensitivity of Mycobacterium leprae to Telacebec

Ramanuj Lahiri,Linda B Adams,Sangeeta Susan Thomas,Kevin Pethe

EMERGING INFECTIOUS DISEASES（2022）

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摘要

The treatment of leprosy is long and complex, benefiting from the development of sterilizing, rapidly-acting drugs. Reductive evolution made Mycobacterium leprae exquisitely sensitive to Telacebec, a phase 2 drug candidate for tuberculosis. The unprecedented potency of Telacebec against M. leprae warrants further validation in clinical trials.

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关键词

Hansen disease,Mycobacterium leprae,QcrB inhibitors,bacteria,leprosy,telacebec,terminal oxidase,tuberculosis and other mycobacteria

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