PET ligands [
18
F]LSN3316612 and [
11
C]LSN3316612 quantify
O
-linked-β-
N
-acetyl-glucosamine hydrolase in the brain
Shuiyu Lu,Mohammad B. Haskali,Kevin M. Ruley, Nicolas J.-F. Dreyfus,Susan L. DuBois,Soumen Paul,Jeih-San Liow,Cheryl L. Morse,Aneta Kowalski,Robert L. Gladding, Jeremy Gilmore,Adrian J. Mogg, S. Michelle Morin, Peter J. Lindsay-Scott,J. Craig Ruble,Nancy A. Kant,Sergey Shcherbinin,Vanessa N. Barth,Michael P. Johnson, Maria Cuadrado, Enrique Jambrina,Andrew J. Mannes, Hugh N. Nuthall,Sami S. Zoghbi,Cynthia D. Jesudason,Robert B. Innis,Victor W. Pike Science Translational Medicine（2020）
摘要
Two radioligands, [ 18 F]LSN3316612 and [ 11 C]LSN3316612, image and quantify brain O -linked-β- N -acetyl-glucosamine hydrolase in vivo.
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