Nicotinamide for skin cancer chemoprevention: effects of nicotinamide on melanoma in vitro and in vivo

Rashi Malesu,Andrew J. Martin,J. Guy Lyons,Richard A. Scolyer,Andrew C. Chen,Catriona A. McKenzie,Jason Madore,Gary M. Halliday,Diona L. Damian

Photochemical & Photobiological Sciences（2020）

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摘要

Nicotinamide is chemopreventive against keratinocyte cancers but its effects on melanoma are unknown. Clinically-achievable nicotinamide doses do not enhance melanoma viability, proliferation or invasion and enhance tumour-infiltrating lymphocytes.

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