Protein Secondary Structure Prediction Approaches

The prediction of protein secondary structure from a protein sequence provides useful information for predicting the three-dimensional structure and function of the protein. In recent decades, protein secondary structure prediction systems have been improved benefiting from the advances in computational techniques as well as the growth and increased availability of solved protein structures in protein data banks. Existing methods for predicting the secondary structure of proteins can be roughly subdivided into statistical, nearest-neighbor, machine learning, meta-predictors, and deep learning approaches. This chapter provides an overview of these computational approaches to predict the secondary structure of proteins, focusing on deep learning techniques, with highlights on key aspects in each approach.