A reprogramming human T cell function and specificity with non-viral genome targeting

Roth TL,Puig-Saus C,Yu R,Shifrut E,Carnevale J,Li PJ,Saco J,Krystofinski P,Li H,Tobin V, Nguyen DN, Lee MR, Putnam AL, Ferris AL, Chen JW,Schickel JN,Pellerin L,Carmody D,Alkorta-Aranburu G,Del Gaudio D,Matsumoto H, Morell M,Mao Y,Cho M, Quadros RM, Gurumurthy CB,Smith B,Haugwitz M, Hughes SH, Weissman JS,Schumann K, Esensten JH, May AP,Ashworth A, Kupfer GM,Greeley SAW,Bacchetta R,Meffre E,Roncarolo MG,Romberg N, Herold KC,Ribas A, Leonetti MD,Marson A

Yearbook of Paediatric Endocrinology（2019）

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摘要

This article decries a CRISPR-Cas9 genome-targeting system that does not require viral vectors, allowing rapid and efficient insertion of large DNA sequences at specific sites in the genomes of primary human T cells, while preserving cell viability and function.

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关键词

genome,cell,reprogramming,non-viral

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