Multiple Copies of qnrA1 on an IncA/C ₂ Plasmid Explain Enhanced Quinolone Resistance in an Escherichia coli Mutant

Laura Vinué, Mohamad R. A. Sater,Ian Herriott,Miriam H. Huntley,George A. Jacoby,David C. Hooper

Antimicrobial Agents and Chemotherapy（2019）

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摘要

In a previous study, mutants with enhanced ciprofloxacin resistance (Cip r ) were selected from Escherichia coli J53/pMG252 carrying qnrA1 . Strain J53 Cip r 8-2 showed an increase in the copy number and transcription level of qnrA1 . We sequenced the plasmids on Illumina and MinION platforms.

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Multiple Copies of qnrA1 on an IncA/C 2 Plasmid Explain Enhanced Quinolone Resistance in an Escherichia coli Mutant

Multiple Copies of qnrA1 on an IncA/C ₂ Plasmid Explain Enhanced Quinolone Resistance in an Escherichia coli Mutant