Negative symptoms in First-Episode Schizophrenia related to morphometric alterations in orbitofrontal and superior temporal cortex: the OPTiMiSE study.

Arsime Demjaha,Silvana Galderisi, Birthe Glenthøj,Celso Arango,Armida Mucci,Andrew Lawrence,Owen O'Daly,Matthew Kempton,Simone Ciufolini,Lone Baandrup,Bjørn H Ebdrup,Roberto Rodriguez-Jimenez, Maria Diaz-Marsa,Covadonga Martinez Díaz-Caneja,Inge Winter van Rossum,Rene Kahn,Paola Dazzan,Philip McGuire

Psychological medicine（2022）

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摘要

The findings highlight the role of orbitofrontal and temporal cortices in the pathogenesis of negative symptoms of Schizophrenia. As they were evident in generally untreated FEP patients, the results are unlikely to be related to effects of previous treatment or illness chronicity.

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关键词

Cortical thickness,FreeSurfer,first-episode psychosis,negative symptoms,voxel-based morphometry

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