Activity of 2-benzyl-1-(2-hydroxyethyl)-5-nitroindazolin-3-one on Trypanosoma cruzi Bloodstream Trypomastigotes (Y strain): In Vitro and In Vivo Studies

Cristina Fonseca-Berzal,Cristiane França da Silva, Marcos Meuser Batista,Francisca Hildemagna Guedes-da-Silva, Mariane Vasconcelos,Kelly C. Demarque,José A. Escario,Vicente J. Arán,Maria de Nazaré C. Soeiro,Alicia Gómez-Barrio

Proceedings of the 1st Molecules Medicinal Chemistry Symposium, Barcelona, Spain（2017）

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摘要

Benznidazole and nifurtimox, the currently available drugs for the specific treatment of Chagas disease, show limited effectiveness and high toxicity that prompt the identification of therapeutic alternatives. [...]

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