Synthesis of D-manno-heptulose via a cascade aldol/hemiketalization reaction

Beilstein Journal of Organic Chemistry(2017)

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摘要
A [4 + 3] synthesis of D-manno-heptulose is described. The cascade aldol/hemiketalization reaction of a C4 aldehyde with a C3 ketone provides the differentially protected ketoheptose building block, which can be further reacted to furnish target D-manno-heptulose.
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