Retraction Note: The NAD-dependent deacetylase SIRT2 is required for programmed necrosis

Nisha Narayan,In Hye Lee,Ronen Borenstein,Junhui Sun,Renee Wong,Guang Tong,Maria M. Fergusson,Jie Liu,Ilsa I. Rovira,Hwei-Ling Cheng,Guanghui Wang,Marjan Gucek,David Lombard, Fredrick W. Alt,Michael N. Sack,Elizabeth Murphy,Liu Cao,Toren Finkel

Nature（2014）

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摘要

We retract this Article because some of the data, specifically the data reported in Fig. 2 demonstrating an in vitro requirement for Sirt2 in TNF-α-mediated necroptosis, appears to be irreproducible. We and others have confirmed that Sirt2 and RIP3interact, and we continue to believe that the absence of Sirt2 protects against ischaemic myocardial damage.

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Acetylation,Science,Humanities and Social Sciences,multidisciplinary

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