Making a leaner Hedgehog
Nature Chemical Biology（2013）
摘要
Secreted Hedgehog (Hh) proteins are essential in development, and their aberrant activity contributes to certain cancers. Chemically targeting a lipid modification of Hh proteins results in loss of their cellular activity, revealing new strategies for cancer intervention and elucidation of the role of lipids in signal transduction.
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关键词
Cancer therapy,Cell signalling,Lipids,Target identification,Chemistry/Food Science,general,Biochemical Engineering,Biochemistry,Cell Biology,Bioorganic Chemistry
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