Preclinical retinal neurodegeneration in a model of multiple sclerosis

Ever since the pathology of multiple sclerosis (MS) was described, it has been debated whether immune-mediated myelin damage is a primary or secondary event to axon degeneration. Traditionally the disease is considered to ensue as a consequence of demyelination followed by neuronal loss. Recent in vivo findings, however, demonstrate axons to be the primary target of the disease process. Animal models of MS are greatly instrumental in studying the pathogenesis of the disease and understanding the sequence of events that take place in neurodegenerative disorders. DOI: 10.5214/ans.0972.7531.190307