Synthesis and Antiprotozoal Activity of Some New Synthetic Substituted Quinoxalines.

Xu Hui,Julie Desrivot,Christian Bories,Philippe M. Loiseau,Xavier Franck,Reynald Hocquemiller,Bruno Figadere

ChemInform（2006）

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摘要

A series of 29 new quinoxalines was synthesized and evaluated in vitro against several parasites (Leishmania donovani, Trypanosoma brucei brucei, and Trichomonas vaginalis). Several of them displayed interesting activities, and particularly four quinoxaline amides showed in vitro antileishmanial properties (IC50 less than 20 microM).

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