1-Phenyl-8-azabicyclo[3.2.1]octane Ethers: A Novel Series of Neurokinin (NK1) Antagonists.

Ian T. Huscroft,Emma J. Carlson,Gary G. Chicchi,Marc M. Kurtz, Clare London,Piotr Raubo,Alan Wheeldon,Janusz J. Kulagowski

ChemInform（2006）

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摘要

Abstract 1-Phenyl-8-azabicyclo[3.2.1]octane ethers are NK1 receptor antagonists. Substitution at the 6-exo-position led to high affinity NK1 antagonists with a prolonged duration of action in vivo. Incorporation of an α-methyl substituent in the pendent benzyl ether side chain gave compounds with increased selectivity over the hERG channel.

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