Discovery of New Chemical Leads for Prostaglandin D2 Receptor Antagonists.

Kazuhiko Torisu,Kaoru Kobayashi,Maki Iwahashi, Hiromu Egashira,Yoshihiko Nakai,Yutaka Okada,Fumio Nanbu,Shuichi Ohuchida,Hisao Nakai,Masaaki Toda

ChemInform（2004）

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摘要

Abstract A series of Indomethacin analogs were synthesized and biologically evaluated. Among the compounds tested, N-(p-butoxy)benzoyl-2-methylindole-4-acetic acid 2 was discovered as a new chemical lead for a prostaglandin D2 (PGD2) receptor antagonist. Structure–activity relationship data are also presented.

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