One-Pot Syntheses of 6-Mercaptopurines (6MP) from 4,5-Diamino-6-chloro-pyrimidines.

Sagun Tandel,Igor Bliznets,Katalin Ebinger,You-An Ma,Dilip Bhumralkar,Mohan Thiruvazhi

ChemInform（2004）

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摘要

Abstract A one-pot synthesis of 6-mercaptopurines from 4,5-diamino-6-chloro-pyrimidine, an aldehyde and elemental sulfur is presented. The key advantage of this procedure is that it utilizes the in situ generated H2S to convert the chloro to a mercapto group.

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