Alzheimer's Disease Polygenic Scores Predict Changes in Episodic Memory and Executive Function Across 12 Years in Late Middle Age.

Daniel E Gustavson,Chandra A Reynolds,Timothy J Hohman,Angela L Jefferson,Jeremy A Elman,Matthew S Panizzon,Michael C Neale,Mark W Logue,Michael J Lyons,Carol E Franz,William S Kremen

Journal of the International Neuropsychological Society : JINS（2023）

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摘要

Memory is most characteristically impaired in AD, but executive functions are one of the first cognitive abilities to decline in midlife in normal aging. This study is among the first to demonstrate that this early decline also relates to AD genetic influences, even in men CN at baseline.

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关键词

Apolipoprotein E4,Cognitive decline,Executive control,Genotype-phenotype association,Longitudinal studies,Neuropsychology

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