Method of long-term, recurrent, intracerebroventricular infusion of cellular therapy in mice

•The method provides durable access to the cerebral ventricles of mice.•This access enables recurrent intracerebroventricular infusion of cells.•The procedure is minimally invasive and, unlike its predecessors, has few complications even over weeks to months.•This method can be used to investigate adoptive cellular therapies for a wide variety of brain pathologies.