CCL2-mediated monocytes regulate immune checkpoint blockade resistance in pancreatic cancer

Xiaocui Li,Guijun He,Jican Liu,Meizhu Yan,Manru Shen,Linfang Xu,Min An,Jiying Huang,Zhenjun Gao

International Immunopharmacology（2022）

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摘要

•CCL2 induces monocyte infiltration in pancreatic cancer;•CCL2 blockade affects the pancreatic tumor microenvironment;•CCL2 signaling blockade enhances the efficacy of immune checkpoint inhibition;•Antitumor effect of anti-PD1 antibody and CCL2 blockade is CD8-dependent.

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关键词

Pancreatic ductal adenocarcinoma,CCL2,Monocytes,Immunosuppression,Immunotherapy

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