Specific effects of somatic GATA2 zinc finger mutations on erythroid differentiation

Enric Redondo Monte,Georg Leubolt,Roland Windisch,Paul Kerbs,Sayantanee Dutta,Theresa Landspersky,Rouzanna Istvánffy,Robert A J Oostendorp,Linping Chen-Wichmann,Tobias Herold,Monica Cusan,Gunnar Schotta,Christian Wichmann,Philipp A Greif

Experimental Hematology（2022）

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摘要

•GATA2 ZF1 mutants A318T and G320D permit erythroid differentiation.•GATA2 ZF2 mutant L359V blocks erythroid differentiation.•Inhibition of erythropoiesis by GATA2 L359V correlates with downregulation of GATA1.

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关键词

Acute Myeloid Leukemia,Blast Crisis,Chronic Myeloid Leukemia,Differentiation,Erythroid,GATA2,Myeloid Neoplasia

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