The Polarity and Specificity of Antiviral T Lymphocyte Responses Determine Susceptibility to SARS-CoV-2 Infection in Patients with Cancer and Healthy Individuals.

Jean-Eudes Fahrner,Imran Lahmar,Anne-Gaëlle Goubet,Yacine Haddad,Agathe Carrier,Marine Mazzenga,Damien Drubay,Carolina Alves Costa Silva,Eric de Sousa,Cassandra Thelemaque,Cléa Melenotte,Agathe Dubuisson,Arthur Geraud,Gladys Ferrere,Roxanne Birebent,Camille Bigenwald,Marion Picard,Luigi Cerbone,Joana R Lérias,Ariane Laparra, Alice Bernard-Tessier, Benoît Kloeckner,Marianne Gazzano,François-Xavier Danlos,Safae Terrisse,Eugenie Pizzato,Caroline Flament,Pierre Ly,Eric Tartour,Nadine Benhamouda,Lydia Meziani,Abdelhakim Ahmed-Belkacem,Makoto Miyara,Guy Gorochov,Fabrice Barlesi, Alexandre Trubert,Benjamin Ungar,Yeriel Estrada,Caroline Pradon,Emmanuelle Gallois,Fanny Pommeret,Emeline Colomba,Pernelle Lavaud,Marc Deloger,Nathalie Droin,Eric Deutsch,Bertrand Gachot,Jean-Philippe Spano,Mansouria Merad,Florian Scotté,Aurélien Marabelle,Frank Griscelli,Jean-Yves Blay,Jean-Charles Soria,Miriam Merad,Fabrice André,Juliette Villemonteix,Mathieu F Chevalier,Sophie Caillat-Zucman,Florence Fenollar,Emma Guttman-Yassky,Odile Launay,Guido Kroemer,Bernard La Scola,Markus Maeurer,Lisa Derosa,Laurence Zitvogel

Cancer discovery（2022）

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摘要

This study prospectively analyzed virus-specific T-cell correlates of protection against COVID-19 in healthy and cancer-bearing individuals. A disbalance between Th1/Th2 recall responses conferred susceptibility to COVID-19 in both populations, coinciding with selective defects in Th1 recognition of the receptor binding domain of spike. See related commentary by McGary and Vardhana, p. 892. This article is highlighted in the In This Issue feature, p. 873.

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