Typical tumor immune microenvironment status determine prognosis in lung adenocarcinoma

•Immune cells infiltration level in lung adenocarcinoma immune microenvironment were quantified and compared.•Three distinct tumor immune microenvironment subtypes were consistent with cancer immunity cycle in cancer dynamic development.•Immune infiltration status of three subtypes were correlated with significant mutated genes, copy number variation and cancer stemness•Prognostic biomarker lung adenocarcinoma immune microenvironment score model was constructed to assess immune infiltration status, evaluate immunotherapy response, and predict patient prognosis.