Shikonin, a promising therapeutic drug for osteoarthritis that acts via autophagy activation

Anquan Wang,Sheng Fang,Lin Zhong,Ming Lu,Hongxiang Zhou,Wei Huang,Lei Li,Weilu Gao,Zongsheng Yin

International Immunopharmacology（2022）

引用 5|浏览12

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摘要

•Shikonin increases the expression of Aggrecan and Collagen II.•Shikonin inhibits the expression of MMP1 and ADAMTS-5.•Shikonin activates autophagy in IL-1β-induced OA chondrocytes.•Similarly, shikonin also alleviated cartilage degeneration in an OA mouse model.•Shikonin, a promising therapeutic drug for osteoarthritis.

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关键词

Osteoarthritis,Chondrocyte,Shikonin,Autophagy,Beclin-1

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