Case report of Leser-Trelat sign as sequela of an atypical inflammatory process

•Leser-Trelat sign is a rare paraneoplastic syndrome that is associated with malignancies.•The presence of multiple seborrheic keratosis should raised the concern of possible underlying malignancy.•Our case report present a patient that had an abrupt development with the suspicious of colon malignancy.•Final pathology shows an inflammatory mass that contained a foreign body granuloma.