A Meta-Analysis of Bovine Chlamydia Prevalence in Cattle in China from 1989 to 2020.

bovis is a widespread infection disease caused by the mixed infection of , , , and in cattle. Although many studies have investigated infection in cattle, there is no nationwide study on the prevalence of infection in cattle of China. We constructed the first meta-analysis to assess the infection rate and infection risk factors of in cattle in China, and we searched PubMed, ScienceDirect, Chinese Web of Knowledge, Wanfang, and VIP Chinese journal database for studies reporting infection in cattle from April 29, 2020. We collected a total of 563 publications from 1989 to 2019, and finally, 78 studies were eligible, which included 152,364 cattle from 27 provinces across the country. We estimated the pooled prevalence of in cattle was 14.2% (95% confidence interval [CI]: 12.2 to 16.4). The prevalence of bovine in China collected before 2000 (14.8%, 95% CI: 5.6 to 27.3) showed the highest prevalence rate. The highest prevalence was found in Central China (22.6%, 95% CI: 12.8 to 34.2). The prevalence of between abortion cattle (39.1%, 95% CI: 24.6 to 54.6) and healthy cattle (8.3%, 95% CI: 3.1 to 15.2) showed significant variation ( < 0.05). In detection methods subgroup, enzyme-linked immunosorbent assay (30.5%, 95% CI: 21.5 to 40.3) showed the highest prevalence. In the age subgroup, the prevalence rate of age >1 year (16.6%, 95% CI: 12.6 to 20.9) was higher compared with age ≤1 year (9.8%, 95% CI: 6.7 to 13.3). Yaks (17.8%, 95% CI: 13.3 to 22.8) showed the highest prevalence among the varieties of bovine. We also estimated the potential risk factors such as feeding model, sample classification, sampling seasons, bovine gender, parity, and quality level of included studies. Our findings suggested that was prevalent in cattle in China. So we should pay attention to bovine and take necessary measures to prevent it.