TDP-43-associated atrophy in brains with and without frontotemporal lobar degeneration

Marina Buciuc,Peter R. Martin,Nirubol Tosakulwong,Melissa E. Murray,Leonard Petrucelli,Matthew L. Senjem,Anthony J. Spychalla,David S. Knopman,Bradley F. Boeve,Ronald C. Petersen,Joseph E. Parisi,R. Ross Reichard,Dennis W. Dickson,Clifford R. Jack, Jennifer L. Whitwell,Keith A. Josephs

NeuroImage: Clinical（2022）

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摘要

•Rates of anterolateral temporal lobe atrophy are faster in FTLD-TDP versus AD-TDP.•Older age is associated with slower frontal lobe atrophy in FTLD-TDP.•AD-TDP type-α showed faster medial temporal atrophy than type-β.•Pure-TDP was associated with slowest rates and less atrophy in all brain regions.

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关键词

AD,ADNC,CA1,CERAD,FTLD,LBD,MCI,NFT,SPM,TDP-43,TIV

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