NPY derived from AGRP neurons controls feeding via Y1 and energy expenditure and food foraging behaviour via Y2 signalling

Yue Qi,Nicola J Lee,Chi Kin Ip,Ronaldo Enriquez,Ramon Tasan,Lei Zhang,Herbert Herzog

Molecular Metabolism（2022）

引用 9|浏览11

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摘要

•Neuropeptide Y (NPY) in AGRP neurons is required to initiate and maintain a feeding drive.•NPY controls feeding and RQ via Npy1r signalling.•NPY controls energy expenditure and activity via Npy2r signalling.•Reduced NPY levels in AGRP neurons result in increased Npy2r expression in POMC neurons.

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关键词

NPY,Food intake,Obesity,Knockout mice,AGRP,Npy1r

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