Acidic environments trigger intracellular H+-sensing FAK proteins to re-balance sarcolemmal acid-base transporters and auto-regulate cardiomyocyte pH.

Abigail D Wilson,Mark A Richards,M Kate Curtis,Mala Gunadasa-Rohling,Stefania Monterisi,Aminah A Loonat,Jack J Miller,Vicky Ball,Andrew Lewis,Damian J Tyler,Anna Moshnikova,Oleg A Andreev,Yana K Reshetnyak,Carolyn Carr,Pawel Swietach

Cardiovascular research（2022）

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摘要

Cardiomyocytes fine-tune the expression of pHi-regulators so that pHi is at least 7.0. This autoregulatory feedback mechanism defines physiological pHi and protects it during pHe vulnerabilities.

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关键词

Acidity,Cardiomyocyte,Homeostasis,Ischaemia,pH sensor

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