Inhibition of TRPA1 Attenuates Oxidative Stress-induced Damage After Traumatic Brain Injury via the ERK/AKT Signaling Pathway

Xin-Jie Yang,Shizhang Ling,Meng-Liang Zhou,Hong-Ji Deng,Min Qi,Xi-Lin Liu,Cheng Zhen,Yun-Xiao Chen,Xi-Ran Fan,Ze-Yu Wu,Feng-Chun Ma, Jun Rong,Guang-Fu Di,Xiao-Chun Jiang

Neuroscience（2022）

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摘要

•Traumatic brain injury features Ca2+/reactive oxidative species-related apoptosis.•Traumatic brain injury was modeled in vitro and in vivo.•Traumatic brain injury upregulated TRPA1 expression via Nrf2.•TRPA1 inhibition reduced apoptosis partly via CaMKII/AKT/ERK signaling.•Blockade of TRPA1 might be developed as a treatment for traumatic brain injury.

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关键词

AKT,CaMKII,ERK,Nrf2,ROS,TBI,TRPA1

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