Antiviral metabolite 3′-deoxy-3′,4′-didehydro-cytidine is detectable in serum and identifies acute viral infections including COVID-19

Ravi Mehta,Elena Chekmeneva,Heather Jackson,Caroline Sands,Ewurabena Mills,Dominique Arancon,Ho Kwong Li,Paul Arkell,Timothy M Rawson,Robert Hammond,Maisarah Amran,Anna Haber,Graham S Cooke,Mahdad Noursadeghi,Myrsini Kaforou,Matthew R Lewis,Zoltan Takats,Shiranee Sriskandan

Med（2022）

引用 8|浏览13

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摘要

•Global metabolic profiling of serum from patients with suspected infection presenting to ED•Single metabolite differentiates viral from bacterial infections and other unwell controls•Identified as ddhC, a free base of only known human antiviral small molecule•ddhC has a key potential role as rapid diagnostic for viral infections

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关键词

ddhC,viral,COVID-19,bacterial,biomarker,metabolomics,mass spectrometry,antiviral,serum,diagnostic

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