Impairment of spatial memory and dorsal hippocampal synaptic plasticity in adulthood due to adolescent morphine exposure

Progress in Neuro-Psychopharmacology and Biological Psychiatry(2022)

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摘要
Opioid exposure during adolescence, a crucial period of neurodevelopment, has lasting neurological and behavioral consequences and affects the cognitive functions in adulthood. This study investigated the effects of adolescent morphine exposure in spatial learning and memory and synaptic plasticity of the CA1 area of the dorsal hippocampus.
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关键词
Adolescence,Hippocampus,Morphine,Morris water maze,In vitro field potential recording
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