Genital Immune Cell Activation and Tenofovir Gel Efficacy: A Case-Control Study

Lenine J P Liebenberg,Jo Ann S Passmore,Farzana Osman,Janine Jewanraj,Andile Mtshali,J Gerardo Garcia-Lerma,Walid Heneine,Angela Holder,Derseree Archary,Sinaye Ngcapu,Aida Sivro,Leila E Mansoor,Quarraisha Abdool Karim,Salim S Abdool Karim,Lyle R McKinnon

CLINICAL INFECTIOUS DISEASES（2022）

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摘要

Genital inflammation (GI) undermines topical human immunodeficiency virus (HIV) pre-exposure prophylaxis (PrEP) efficacy through unknown mechanisms. Here, associations between activated endocervical CD4 + T-cell numbers and higher deoxyadenosine triphosphate (dATP) concentrations suggest that competition for intracellular metabolites within HIV target cells may reduce the efficacy of antiretroviral-based PrEP in women with GI.

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关键词

immune activation, genital inflammation, HIV, tenofovir, dATP

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