Improved Hematologic Outcomes in HIV1-Exposed Infants Receiving Nevirapine Compared With Zidovudine for Postnatal Prophylaxis in a High Resource Setting

Catherine Dollfus,Jérome Le Chenadec,Laurent Mandelbrot,Roland Tubiana,Albert Faye,Maud Brossard,Pierre Frange,Stéphane Blanche,Josiane Warszawski

PEDIATRIC INFECTIOUS DISEASE JOURNAL（2022）

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摘要

In the ANRS French Perinatal Cohort, we compared outcomes in 830 HIV1-exposed infants who received either nevirapine (NVP) or zidovudine postnatal prophylaxis. At 1 month, anemia grade >= 2 was less frequent on NVP than zidovudine (2.9% vs. 8.0%; P = 0.01), favoring the use of NVP as a first choice prophylaxis in infants at low risk of HIV acquisition.

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关键词

HIV1, perinatal transmission, anemia, nevirapine, zidovudine

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