Cardiac Gene Therapy With Relaxin Receptor 1 Overexpression Protects Against Acute Myocardial Infarction

Teja Devarakonda,Adolfo G Mauro,Chad Cain,Anindita Das,Fadi N Salloum

JACC: Basic to Translational Science（2022）

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摘要

•AAV9 vectors can upregulate Rxfp1 mRNA in murine heart after intravenous injection.•RXFP1 upregulation sensitizes the left ventricle to relaxin-induced inotropy.•RXFP1 overexpression protects heart from ischemia-reperfusion injury.

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关键词

gene therapy,ischemia-reperfusion injury,LV function,relaxin,RXFP1

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