Comprehensive analysis of DOK family genes expression, immune characteristics, and drug sensitivity in human tumors

•The expression of DOK family genes is related to overall survival (OS), clinical stage, tumor mutation, methylation, CNV, and SNV.•DOK family genes are significantly associated with poor prognosis of UVM.•DOK1-DOK3 has obvious correlation with tumor immunity and tumor microenvironment.•DOK family gene is significantly related to tumor stemness and drug sensitivity.•The expression of DOK family genes is related to the activation of EMT and hormone ER pathways, and is related to the inhibition of DNA damage response, cell cycle, and hormone AR pathways.•DOK1 and DOK3, DOK2 and DOK3 have the significant correlation.