Positive predictive value of ERBB2 copy number gain by tissue or circulating tumor DNA next-generation sequencing across advanced cancers.

Ami N Shah,Ashwin Sunderraj,Brian Finkelman,Sharlene H See,Andrew A Davis,Lorenzo Gerratana,Firas Wehbe,Neelima Katam,Deva Mahalingam,William J Gradishar,Amir Behdad,Luis Blanco,Massimo Cristofanilli

Oncotarget（2022）

引用 3|浏览6

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摘要

ERBB2 CNG by NGS is detected in numerous malignancies for which HER2 testing is not standard. Detection of ERBB2 CNG by tissue NGS and ctDNA has a high PPV for true HER2-positivity by standard IHC and/or FISH testing in breast cancer.

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关键词

ERBB2,HER2,circulating tumor DNA,copy number gain,next-generation sequencing

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