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Low pKa of Lys promotes glycation at one complementarity-determining region of a bispecific antibody

Xiaobin Xu, Jessica Ann O'Callaghan, Zachary Guarnero,Haibo Qiu,Ning Li,Terra Potocky,Douglas E. Kamen,Kenneth S. Graham,Mohammed Shameem,Teng-Chieh Yang

Biophysical Journal（2022）

Cited 5|Views10
Key words
Arrhenius reaction,bispecific antibody,cation exchange chromatography,glycation,homology modeling,kinetics and thermodynamics,liquid chromatography-mass spectrometry,molecular dynamic simulation
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