Pharmacological mechanism of Shenlingbaizhu formula against experimental colitis

Wei Yu,Guoliang Wang,Chang Lu,Chen Liu,Lu Jiang,Zizheng Jiang,Zhenghao Liang, Xiao Wang,Zheng Qin,Jing Yan

Phytomedicine（2022）

引用 12|浏览2

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摘要

•Network pharmacology integrated with metabonomic analysis was utilized to explore the therapeutic effect of SLBZ formula against experimental colitis.•SLBZ formula improved mucosal healing by inhibiting intestinal stem cell apoptosis under inflammatory milieu.•SLBZ formula restored DSS-altered bacterial flora composition and facilitated the production of gut-friendly metabolites.

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关键词

Inflammatory bowel disease,Ulcerative colitis,Macrophages,Intestinal organoids,Shenlingbaizhu formula

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