Plasma acetyl-L-carnitine and L-carnitine in major depressive episodes: A case-control study before and after treatment

Abd El Kader Ait Tayeb,Romain Colle,Khalil El-Asmar,Kenneth Chappell,Cécile Acquaviva-Bourdain,Denis J David,Séverine Trabado,Philippe Chanson,Bruno Feve,Laurent Becquemont,Céline Verstuyft,Emmanuelle Corruble

FUNDAMENTAL & CLINICAL PHARMACOLOGY（2022）

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摘要

Our data suggest a decreased mitochondrial metabolism of l-carnitine into ALC during MDE. This decreased mitochondrial metabolism is restored after a 6-month antidepressant treatment. Moreover, the magnitude of mitochondrial dysfunction may predict remission after 3 months of antidepressant treatment. New strategies targeting mitochondria should be explored to improve treatments of MDD.

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关键词

major depressive disorder, major depressive episodes, antidepressants, acetyl-L-carnitine, L-carnitine, mitochondria, biomarkers

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