Cross-dressing of dendritic cells strengthens antitumor immunity

Different subsets of tumor infiltrating dendritic cells (DCs) influence immune response and tolerance in cancer settings. Duong et al. discovered that conventional DC2 subset (cDC2s) can differentiate into stimulatory interferon-stimulated gene (ISG)(+) DCs by type I interferon (IFN-I) produced in regressor tumors and acquire and present tumor-derived peptideMHC (pMHC) class I complexes to increase the protective antitumor CD8(+) T cell response.