The impact of the COVID-19 pandemic in exacerbating dementia risk factors in a high-risk Alzheimer's disease population: Study of a cohort with Down syndrome.

The pandemic has had a negative impact on physical and mental health of a large proportion of individuals with DS which in turn may potentially affect dementia risk in this already vulnerable group. Although no causal relationship can be established from this study, the aforementioned worsening in health may have partially resulted from the social isolation, reduced physical and cognitive stimulation recorded in this cohort.