Minocycline as a therapeutic strategy against the brain dysfunctions induced by hypercholesterolemia.

Julia Nostrani Martins,Matheus Scarpatto Rodrigues,Hemelin Resende Farias,Matheus Henrique Rossoni Fossá, Tainá Schons,Josiane Budni,Andreza Fabro de Bem,Jade de Oliveira

Alzheimer's & dementia : the journal of the Alzheimer's Association（2021）

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摘要

Therefore, our results show that administration of minocycline presented promising effects in ameliorating the cognitive and behavioral deficits related to hypercholesterolemia, demonstrating that microglial activation might play a role in the memory deficits induced by this metabolic disease.

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