The pathogenic role of tubulin tyrosine ligase and D2 tubulin in Alzheimer's disease.

Julie Parato,Atul Kumar,Maria Elena Pero,Xiaoyi Qu,Marian Blanca Ramírez,Andrew Sproul,Francesca Bartolini

Alzheimer's & dementia : the journal of the Alzheimer's Association（2021）

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摘要

Together, our results indicate that loss of TTL and accompanying accumulation of D2 tubulin are hallmarks of both sporadic and familial AD and that loss of MT dynamicity is a feature of familial AD that may contribute to synapse loss and disease progression.

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