APOE-e4 alters the microglial phenotype in the presence of Alzheimer's disease pathology compared to APOE-e3.

Courtney M Kloske,Erica M Weekman,Kevin Xie,Ela Patel,Sonya Anderson,Adam D Bachstetter,Josh M Morganti,David W Fardo,Peter T Nelson,Donna M Wilcock

Alzheimer's & dementia : the journal of the Alzheimer's Association（2021）

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摘要

The findings from this study suggest that with APOE- e3, microglia are able to respond in the presence of AD pathology. By contrast, APOE- e4 microglia cannot produce an appropriate response to AD pathology. Overall, these findings help highlight the role of the APOE isoforms in AD and neuroinflammation.

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