The influence of sleep-wake rhythms on AD-related pathology in 3xTgAD mice.

Katharina Kohler, Dianne Gillis, Caitlin Wessel, Lindsay Beechem, Emrakh Askarov, Alex Baker, Frances Salisbury,Jun Wang,Dillon Huffman,Lauren Guerriero,Sridhar Sunderam, Bruce F O'Hara,Adam D Bachstetter,Marilyn J Duncan,Michael Paul Murphy

Alzheimer's & dementia : the journal of the Alzheimer's Association（2021）

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摘要

These findings demonstrate that a protocol for fragmenting the daily sleep-wake rhythm in 3x-TgAD mice can impact the development of AD-related pathology. These studies also support the concept that improving sleep consolidation in individuals at risk for AD may be beneficial for slowing the onset or progression of AD.

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