Non-denaturing affinity purification of soluble oligomeric Aβ from human brain using a novel calcium-sensitive monoclonal antibody.

Andrew Stern,Lei Liu,Wen Liu,David Reczek,Laurent Pradier,Megan Batson,Sagar Kathuria,Tingwan Sun,Dennis J Selkoe

Alzheimer's & dementia : the journal of the Alzheimer's Association（2021）

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摘要

B24 is protective against natural oAβ-induced neuronal injury and binds oAβ in a calcium-dependent manner. This unique characteristic allows affinity purification of bioactive oAβ from human brain extracts for further study and drug development.

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